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ESCs cultured in LIF + FCS or LIF + BMP are restrained from progressing to overt differentiation but free to explore naive and primed states of pluripotency (Nichols and Smith, 2009).
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FGF is necessary but not sufficient to drive lineage commitment: further progression to overt differentiation is restrained by the combination of leukemia inhibitory factor (LIF) and bone morphogenetic protein (BMP) signaling, both of which restrict cells from progressing to a postimplantation epiblast-like state (Ying et al., 2003).
If possible, keep the episode from progressing.
Restrained from governing, he decided to guide.
She was restrained from removing it by a fellow member.
One delegate had to be physically restrained from attacking another.
"You are restrained from doing what you want to do".
An attorney general was restrained from suing to recover penalties imposed by an unconstitutional statute.
Commissions have been restrained from enforcing a statute which illegally burdened interstate commerce.
The real story here is that Skype is restrained from innovating because they don't own their own IP.
Restrained from what?
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