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Agreement with experimental results for the restrained degree of freedom could indicate that calculated free energy landscapes are representative of the experimental regimen.
The PMF approach allows one to obtain the free energy cost for the restrained degree of freedom in both classical MD simulations and QM/MM studies of reaction barriers.
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The control contribution of the restrained protein core degrees of freedom alone yields 0.0 kcal/mol as anticipated.
Palatability (Yeomans et al., 2001), the variety of available foods (Norton et al., 2006), whether the serving dish remains on the table (Payne et al., 2010), the number of people present (de Castro and Brewer, 1992), cognitive distraction (Brunstrom and Mitchell, 2006), and individual differences such as the degree of restrained eating (Herman and Mack, 1975) play a role.
In a two-stage operation the multi-spoked steel structure will be hauled up to a 65 degree angle, the supporting structure restrained and secured, before stage two, in which the wheel will be raised to the vertical.
"I've never seen anyone lose it to that degree," says producer Dan Carey, the more restrained half of SEXWITCH – that's one word, please, and in capital letters.
For the first half of the 20-minute sketch, the dialogue is swift and pungent, and the four performers (Thomas Lyons, Katherine Leask, Joe Urla and Geneva Carr), assuming various degrees of child-rearing expertise, are appealingly restrained and funny.
Each frame was indeterminate to the degree four and comprised a rectangular bay with tip-restrained cantilever extensions to represent beam lengths to contraflexure in adjacent bays.
In concrete structures higher free shrinkage, higher hydration heat, higher restraint degree, higher elastic modulus and lower creep generally lead to a higher restrained stress and, consequently, to a worse micro-cracking tendency (Gao et al. 2012).
The response of such restrained steel beams under fire depends on many factors including fire scenario, load level, degree of restraint at the supports, and high-temperature properties of steel.
Further, the degree of opening in the full-length channel appears to be more restrained than in the open mutant KcsA structural studies.
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