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Restoring the level of chaperone-mediated autophagy by overexpressing LAMP2a, a CMA receptor, decreased the accumulation of damaged proteins and increased organ function [ 183].
Another potential issue with miRNA replacement therapies is the challenge of restoring the level of a downregulated miRNA while preventing the introduction of supraphysiological levels of the miRNA.
Thus, by restoring the level of serum ALT, AST, cholesterol, and TG back to normal, high dose of fermented mung beans has certified its hepatoprotective effects at least in part.
Restoring the level of ubiquitin by overexpresssion does not rescue the sorting defect of ubiquitinated proteins in doa4Δ cells; instead, these proteins remain on the surface of endosomes and subsequently reach the vacuolar membrane.
Another potential issue with miRNA replacement therapies is the challenge of restoring the level of a down-regulated miRNA, while preventing the introduction of supraphysiological levels of the miRNA.
Thus, by restoring the level of serums ALT, AST, GGT, and bilirubin back to normal in alcohol intoxicated rat, a high dose (400 mg/kg/day) of EEAIT has certified its hepatoprotective effects against alcohol intoxication at least in part by reducing fat droplets in liver.
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Besides, Amanda® improved the epithelial barrier function by restoring the levels of villin and mucin MUC3.
To confirm that pravastatin prevents PE in the CBA/J x DBA/2 mice by restoring the levels of VEGF, we treated DBA/J mated CBA/2 females with VEGF121.
reduced toxic effect of CCl4 by restoring the levels of serum marker enzymes to the normalcy.
10.7554/eLife.00429.004 Figure 2. ku540 mutant suppresses L1 arrest of mmBCFA and sphingolipid biosynthetic mutants without restoring the levels of mmBCFAs.
This promotes the utilization of glycogen as a carbon source to replenish the phosphoenolpyruvate levels, thus restoring the levels of phosphorylated PTS proteins [ 102].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com