Sentence examples for restoring endothelial function from inspiring English sources
Adipose-derived stem cells (ASCs) are a potential adult mesenchymal stem cell source for restoring endothelial function in patients with critical limb ischemia.
Although AVE 3085 treatment has been shown to be effective in spontaneously restoring endothelial function in hypertensive rats, little is known about the effects and mechanisms of AVE 3085 with respect to cardiac remodeling.
Recently, Kharitonova et al. have shown a beneficial effect of magnesium supplementation in restoring endothelial function [228].
Interestingly, antioxidants such as vitamin C are capable of restoring endothelial function in patients with HF [ 82].
Importantly, the ability of allogeneic MSCs greatly exceeded that of autologous MSCs in restoring endothelial function, enhancing EPC colony formation, and suppressing VEGF levels.
They concluded that the dual effect on uncoupled eNOS and Nox might explain the high efficacy of angiotensin II antagonists in restoring endothelial function [ 44].
These in vitro and in vivo findings thus provide mechanistic evidence to support published functional studies that have shown that L-phe administration restores endothelial function and attenuates the observed hypertension induced by administration of the GCH1 inhibitor di-amino-hydroxypyrimidine (Mitchell et al., 2004).
These findings reveal a novel mechanism whereby allogeneic, but not autologous, MSC administration results in the proliferation of functional EPCs and improvement in vascular reactivity, which in turn restores endothelial function towards normal in patients with HF.
To restore endothelial function, corneal transplantation is needed.
Cheang et al147 reported that metformin restored endothelial function through inhibiting ERS and oxidative stress and increasing NO bioavailability in activation of the AMPK/PPARδ pathway in obese diabetic mice.
Treatment with enalapril (ACE inhibitor) or valsartan (AT1R blocker) restores endothelial function in OVX female rats.
