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Furthermore, the reduction of Pax7, or the exogenous addition of its downstream targets, like MyoD, reversed muscle wasting by restoring cell differentiation and fusion, under tumor conditions.
Therefore, our findings imply that beta-arrestin-mediated internalization is responsible for eliminating the stable photoproduct and restoring cell conditions to the original dark state.
Therefore, chaperones and proteasome inhibitors may be clinically useful for restoring cell surface expression of "transport –defective or -processing" mutant proteins.
We have shown here that the genes encoding LytM and SsaA are not essential in S. aureus, but that peptidoglycan crosslinking relaxation through pentaglycine cross-bridge cleavage is important in restoring cell viability in the absence of WalKR.
Our results, showing that SsaA behaves differently from the other WalKR-regulon encoded CHAP domain proteins, strongly suggest that the SsaA CHAP domain is also endowed with D-alanyl-glycyl endopeptidase activity, which could explain why it can act as well as LytM in restoring cell viability in the absence of WalKR.
ER stress response represents a protective, pro-survival response, which is aimed at restoring cell homeostasis.
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Since diminished cell-extracellular matrix interactions mediated by α-DG-laminin interaction underlie many phenotypes found in congenital muscular dystrophies, restoring cell-laminin interactions in congenital muscular dystrophies may provide therapeutic benefit.
This suggests that restoration of the ER Ca2+ content alone is not sufficient to fully restore cell adhesion activity.
This is counteracted by adaptive responses that restore cell volume and strengthen the cytoskeletal architecture.
The accumulation of ME TAG might contribute to decrease the cellular toxicity of RA and restore cell growth.
Both W1952* and D1849N restored cell invasion in LN229 and U251MG, though to a different extents (Fig. 4b(i) and (ii)).
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