Sentence examples for restores responsiveness from inspiring English sources
Sabnis, G. J., Goloubeva, O. G., Kazi, A. A., Shah, P. & Brodie, A. H. HDAC inhibitor entinostat restores responsiveness of letrozole-resistant MCF-7Ca xenografts to aromatase inhibitors through modulation of Her-2.
Beeram et al. [48] found that cotreatment with the mammalian target of rapamycin (mTOR) inhibitor RAD-001 reverses the AKT-mediated resistance and restores responsiveness to antiestrogens.
Overexpression of XIAP increases resistance to TRAIL-induced apoptosis, while downregulation of XIAP restores responsiveness to TRAIL [ 17, 18].
A several hour incubation in culture medium with normal Zn2+ fully restores responsiveness to the five active metals.
This occurs despite evidence for increased maturation of B cells in NZB dTg mice, suggesting that entry into the mature B cell pool is insufficient to restore responsiveness to HEL in dTg B cells.
IRPs are bistable and possess two photosensitive states in which photon absorption at one wavelength initiates the phototransduction cascade of the photopigment bound 11-cis-retinal (rhodopsin - R state) while subsequent absorption at a second wavelength photoisomerizes all-trans-retinal (metarhodopsin - M state) back to 11-cis to restore responsiveness [7].
It was predicted that rapamycin can restore responsiveness of aging cells [ 157].
Both promoter constructs only slightly responded to Tg, but the deletion of the three suppressive regions (+11/-396 m1; CRELD2 promoter and -396/+11 m1; ALG12 promoter) restored responsiveness to Tg.
Deletion around three putative Ets family binding sites (TTCC) [ 21, 22] from position -52 to -20 in the ALG12 promoter (-343/-212 & -107/+11 m1) also restored responsiveness to Tg.
The inhibition of P-gp (by suppression of protein expression or reduction of activity) restored responsiveness to 17-DMAG in all resistant cells (Fig. 4e).
The authors concluded that inhibition of both HER2-mediated signaling and mTOR-dependent translation may restore responsiveness to letrozole in breast cancer refractory to this AI [ 43].
