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In our work, we confirmed that the increasing the level of HDL3-associated S1P restores its function similar to what is observed with HDL from diabetic subjects.
In vivo manipulation of FOXN1 expression, which not only enlarges the aged thymus but also restores its function, therefore presents a promising alternative strategy for clinical thymus regeneration – for instance by small molecule manipulation of signaling pathways that regulate FOXN1 expression or directly augment FOXN1 function.
However, it has long been known that forced trafficking of CFTR-ΔF508 to the plasma membrane - for example, by growing cells at low temperature - at least partly restores its function, because the CFTR-ΔF508 mutation does not have a strong impact on the actual biological function of the CFTR protein.
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She once took apart the family's broken answering machine, decided that a few parts seemed out of place, and put it back together again, restoring its function.
The methylase inhibitor can reverse NGX6 expression in colorectal cancer, and it is possible to restore its function as tumor suppressor gene at some a degree.
The first therapeutic attempt to restore its function by selectively designed novel drugs are being made.
In these approaches, the goal is to integrate new cells into the retina to help restore its function.
Cells should graft, survive and functionally integrate to the target organ in order to have a chance to restore its function.
Consequently, there is also the need to perform a significant number of studies of repairing procedures of structural elements, so as to restore its function and possibly achieve an improvement in relation to its original seismic resistance.
Successful outcome after arthroscopic hip surgery depends on appropriately reshaping the bony architecture to allow for improved range of motion before impingement symptoms occur, with special attention to preserve the labrum and restore its function.
The stem cells migrating into the ECM bio-implant are directed by the ECM to differentiate into cells that regenerate the bio-implant and restore its function without being negatively affected by the anti-non gal antibodies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com