The OKR is also well suited for quantifying the functional response to stem cell, pharmacologic, or genetic approaches aimed at restoring vision in the context of retinal degenerative diseases.
This type of drug would be beneficial for treating diseases where AKT activity is limited, such as for restoring insulin sensitivity in the context of diabetes mellitus.
We conclude that increased membranous expression of junctional molecules (E-cadherin and β-catenin) by 5-ASA contributes to intercellular adhesion, which could potentially impede with neoplastic progression and restore epithelial integrity in the context of UC.
PCC offers a rapid method for replacing vitamin K dependent clotting factors and restoring normal haemostasis in the context of over-anticoagulation, being quicker to prepare than fresh frozen plasma (FFP) and allowing administration without warming [ 16– 16].
In addition, we are using imaging and electrophysiology to determine the functional impact of mTOR signaling perturbations, and test approaches to restore balanced mTOR activity in the context of disease.
To test this hypothesis, we first attempted deleting one copy of GAL80 in the disomic strain, thereby restoring GAL80 copy number in the context of an otherwise aneuploid strain.
Indeed, if there is a tight size constraint, and at the same time, a characteristic rate of gene duplication, there also should be some force to maintain and restore functional diversity, especially, in the context of a community genome, and HGT is the best and obvious candidate.
Intense research is conducted to identify microRNAs susceptible to be used as biomarkers and to design new therapeutic approaches based upon using synthetic microRNA mimics and inhibitors as well as finding new drugs capable to restore or modify microRNA expression in the context of gut pathologies.
We further demonstrate that inactivation of the argonaute gene, rde-1, a critical regulator of RNA interference, completely restores lifespan to normal levels in the context of adr-1 and adr-2 loss of function.
We therefore asked whether restoring the hydrophobicity of Φ3 or Φ4 in the context of the L4A mutation could restore the four hydrophobic positions required for CRM1 binding and, in turn, nuclear exclusion.
