23 34 35 40 53 62 The RESTORE trial included patients with macular ischaemia and undertook a subgroup analysis.
The cost effectiveness of ranibizumab in DME was evaluated from evidence gathered in the RESTORE trial.
Patients receiving 2 mg q8wk and 2 mg PRN received similar numbers of injections (7.2 and 7.4) as those in the RESTORE trial (7).
The findings of the REVEAL are consistent with the RESTORE trial; that ranibizumab monotherapy can result in rapid and significant improvement in vision and reduction in CRT compared with laser alone.
The Phase III RESTORE trial enrolled 345 patients with visual impairment due to DME and assessed ranibizumab given either as monotherapy or in combination with laser photocoagulation, compared with laser photocoagulation alone.
This report summarises the results of a health economic model that was developed based on RESTORE trial data to evaluate the cost-effectiveness of ranibizumab from a UK payer perspective when used as monotherapy or in combination with laser therapy compared with laser therapy alone.
A Markov model was constructed to simulate costs and changes in BCVA over a 15-year period in a hypothetical cohort of patients with DME (figure 1), based on data from the RESTORE trial (in which 87.5% of patients had type 2 diabetes and average baseline glycated haemoglobin was 7.3%).
The results of our model may be applicable to a broad spectrum of patients with visual impairment due to DME, as the RESTORE trial showed consistent efficacy of ranibizumab therapy across patient subgroups based on a range of demographic and disease characteristics.
If we do not act on this opportunity to refurbish and restore abandoned trials, the medical research community will be failing its moral pact with research participants, patients, and the public.
After this he restored treason trials, showed great cruelty, and engaged in wild despotic caprice; e.g., he bridged the Bay of Naples with boats from Baiae to Puteoli in the summer of 39.
