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There is no evidence that any of these drugs reverse β cell de-differentiation or restore the functionally mature β cell mass after β cell de-differentiation has occurred (Kahn et al., 2006; Accili et al., 2010).
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The converse light-induced conversion from the 13- cis,15- syn- to all- trans-form is called light-adaptation and restores the functionally active state for most microbial rhodopsins.
Since p53 aberrations are commonly involved in PDAC tumorigenesis [ 43, 44], it is tempting to speculate whether Sirt1 inhibition may help to restore the remaining functionally intact p53 pool.
... Our results suggest that DBS in the STN could functionally restore the TC relay activity, while DBS in the GPe and in the GPi could functionally over-activate and inhibit it, respectively.
Whilst the rescue of the pump duration and R/E-spike ratio suggests the exogenous expression of slo-1a in the pharyngeal muscle is sufficient to functionally restore the normal behavior of the muscle.
Among numerous treatment options currently available in clinical practice, osteochondral transplantation is the only biological technique that can anatomically and functionally restore the hyaline cartilage [ 3– 9].
Reviewer 1: Ruffault et al test the functional role of neurons located in the retrotrapezoid nucleus (RTN) in the control of constant CO2 and H+ concentrations in the arterial blood by genetic strategies allowing them to functionally ablate or restore the activity of a subset of RTN cells expressing the transcriptional factors Atoh1 and Phox2b.
] Reviewer 1: Ruffault et al test the functional role of neurons located in the retrotrapezoid nucleus (RTN) in the control of constant CO 2 and H + concentrations in the arterial blood by genetic strategies allowing them to functionally ablate or restore the activity of a subset of RTN cells expressing the transcriptional factors Atoh1 and Phox2b.
Functionally, these changes serve to restore the cutaneous barrier and protect the organism.
Purified recombinant subunit IV is functionally active as it can restore the bc1 complex activity from the three-subunit core complex to the same level as that of wild-type or complement complex.
A-MuLV-derived gag sequences could, however, functionally replace the 5' end of src and restore the transformation potential of a 5'-truncated src gene.
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