Sentence examples for restore the effect of from inspiring English sources

However, as our model is focusing neither on the genetic nature of the adaptive landscape, nor on the rate of adaptation (ruggedness means that several mutations could be needed to restore the effect of one) it should not be too sensitive to the small level ruggedness of the genetic landscape described so far.

Over-expression of Pbx1 in PM precursors after the 3-somite stage slowed down axis elongation, suggesting that Pbx1 can restore the effect of anterior Hox genes on ingression during this time window.

Since the muscarinic M1 subtype of cholinergic receptors inhibit apamin-sensitive SK2 channels in the rat hippocampus [ 13] we tested whether the muscarinic M1 receptor allosteric agonist TBPB could restore the effect of LPS treatment on AHPs.

Preincubation of aortic rings with either a combination of cell-permeable PEG-SOD and PEG-cat or the selective peptide inhibitor of NADPH oxidases, gp91ds- dat, failed to restore the effect of ACh in ATGL deficiency (Fig. 1C).

Given the hypothesis that Abcg2 overexpression is responsible for resistance to Danusertib, we investigated whether the inhibition of Abcg2 activity with its specific inhibitor FTC was able to restore the effects of Danusertib treatment in vitro.

First, the present work showed that 3-day recovery after removal of suspension could completely restore the effects of simulated microgravity on the function of ryanodine-sensitive Ca2+ releases from SR in cerebral and small mesenteric VSMCs of rats (Fig. 6).

In addition, several common medications have been shown to restore the effects of IPC, which are lost due to an underlying comorbidity.

Carvedilol has been shown to restore the effects of IPC in a rat model of coronary artery stenosis (Oikawa et al., 2008), and humans resistant to IPC were rendered responsive to IPC by pre-treatment with enalaprilat (Ungi et al., 2008).

Incubation with pertussis toxin (PTX) largely restored the effect of β1AR in PMI cells (86.6% vs. SHAM cells), but did not affect β1AR response in SHAM cells.

Addition of exogenous TNF-α and IFN-γ together enhanced DC maturation and completely restored the effect of blocking P-gp after LPS addition (Figure 6f i), whereas addition of these cytokines separately did not affect DC maturation (data not shown).

Adding back the autologous CD4+ T cells fully restored the effect of CTLA-4 blockade on TGF-β-, IL-10-, and IFN-γ-positive HIV-specific CD8+ T cells.