In turn, p53 loss restored the development of Rpl22-deficient thymocytes.
Complementation of the dapAX mutation in vivo required the introduction of both genes in trans, either in single or multiple copy, and this restored the development of plague to near wild type levels.
Expression of exogenous rat NF-H was able to compensate for knockdown of endogenous NF-H and restored the development and stabilization of axonal neurites.
Indeed, depletion of CD25+ Tregs restored the development of the Th1 response in IL-6RαT-KO mice, while the Th17 response was not rescued, which is consistent with the role of IL-6 in the differentiation of Th17 cells.
"Our choices now will determine whether we restore the rapid development of this region or let decades of social progress towards the Millennium Development Goals erode," said Indonesian Finance Minister, Dr. Sri Mulyani Indrawati.
Calling for action on debt reduction, trade and aid to restore the momentum to development, the report argues that the derailment of the development effort also offers an opportunity to re-examine its direction.
However, apoptosis is unlikely to be the main reason for the failure of T cell development upon loss of Bcl11b, because inactivation of p53 in mutant thymocytes is not sufficient to fully restore the T cell development, even though some immature single-positive (ISP) T cells are indeed detected in Bcl11b -/- p53 -/- embryos [ 130].
Importantly, we find a developmental window in which treatment with a MEK inhibitor can restore the normal early development of the embryo, without the additional, unwanted developmental effects of the drug.
Secondary compensatory mechanisms can however restore the costs of resistance development [18], [19].
When it comes to restoring the buildings, the development corporation will have its work cut out for it.
Correction of these deficiencies depends on regulation of biologic pathways of embryonic and fetal development to restore the full anatomy and physiology of uninjured skin.
