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These two compounds bind to XIAP and cIAP-1/2 with low nanomolar affinities, and restore the activities of caspase-9 and caspase-3/-7 inhibyted by XIAP.
Extracellular matrix (ECM) derived from mesenchymal stem cells (MSCs) has recently been shown to be able to maintain the differentiation potential of MSCs during culture expansion and to restore the activities of aging MSCs, suggesting that MSC ECM (MECM) may be a suitable culture substrate to enhance the bioactivity of biomaterial scaffolds for MSCs.
Treatment with DNA methylation inhibitors can restore the activities of CDH13 gene and decrease the growth rate of cancer cells.
Treatment with DNA methylation inhibitors can restore the activities of the CDH13 gene and decrease the growth rate of cancer cells.
As reported from the earlier studies of our laboratory, the protein could scavenge DPPH radicals as well as restore the activities of different antioxidant enzymes and attenuate various toxin-induced enhancement of lipid peroxidation [ 31- 34].
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Many studies provide tantalizing evidence that small-molecule drugs can restore the activity of p53 and activate apoptosis in mutp53-carrying tumor cells.
That is to say that increased levels of external auditive noise can activate internal noise and restore the activity level.
Discovery of second site mutations that restore the activity of some of these mutants has provided clues for the restoration of activity by the use of small molecules.
Agents that restore the activity of hair stem cells in male pattern baldness are under investigation.
However, compensatory remodeling of the other partner in the pair, may restore the activity.
Administering chemotherapeutics along with silencing resistance-basis activity using RNA interference (RNAi) is expected to restore the activity of the chemotherapeutic and generate synergistic cancer eradication.
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