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In parallel to the transcriptome analysis, we performed unbiased shRNA re-sensitization screens to identify kinases whose suppression restore sensitivity to crizotinib in SMARCE1-knockdown cells, using a lentiviral shRNA library representing the full complement of 518 human kinases.
Moreover, inhibition of drug transporter function and/or restoration of drug accumulation has only limited to no ability to restore sensitivity to chemotherapy agents.
Corticosteroids have been used to mitigate mineralocorticoid-related effects and restore sensitivity to abiraterone acetate.
To test this hypothesis and restore sensitivity, a new primer set for detection of the possible C-strain virus quasi species was designed and tested.
To restore sensitivity, electrodes were periodically replated with Hg and polarized at −9 V for 90 s.
Therefore, only masitinib was able to restore sensitivity to gemcitabine in Mia Paca2 cells.
Small-molecule inhibitors of proapoptotic BCL2 family members can restore sensitivity to some therapeutic agents that induce apoptosis [36].
Co-inhibition of BCL-W and BCL2 is both necessary and sufficient to restore sensitivity to ICI, and explains mechanistically the action of YC137.
However, this supplementation to the medium did not restore sensitivity of C7 treated strains to K1F phage lysis, suggesting that K1 capsule was not produced (data not shown).
The ability of NSC23925 to restore sensitivity to the cytotoxic effects of chemotherapy or to prevent resistance could significantly benefit cancer patients.
Thus, targeting HIF-1 is expected to synergize with the anti-angiogenesis treatment and other treatments that promote hypoxia and restore sensitivity to drugs.
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