Indeed, we found that the expression of Vav1WT is capable of completely restoring development and activation of VavNULL T cells.
The linkage between lipid accumulation and Rif resistance was strongly supported by the finding that complementation of tgs1 mutant restored development of Rif resistance.
Together, these results show that GEF-inactive Vav1 is capable of restoring development of T cells lacking all endogenous Vav family proteins.
The dapAX mutation rendered Y. pestis avirulent in mouse models of bubonic and septicemic plague which could be complemented when dapAX was inserted in single or multi-copy, restoring development of disease that was indistinguishable from the wild type parent strain.
Similarly, we found that restoring development of bps1 roots (by GSH provision to bps1 rml1-1 seedlings) reinstated arrest of leaf development.
The overlapping expression patterns of MIR168a and AGO1 and the restored development and fertility in ago1 mutants expressing miR168a-promoter:AGO1 fusion support this model [ 26].
We envision that in the long run, computational models will become important tools for understanding biological systems, for the identification of precise causes of abnormal development, and possibly disclose ways to restore normal development and function.
Third, will Labour policy seek to restore regional development agencies or build on the government's new local enterprise partnerships?
