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The resting zone cells divide slowly and result in rapidly dividing proliferative cells which are arranged in orderly columns along the long axis of the bone.
Both 75:25 poly (l-lactide-co-ε-caprolactone) (75PLC) and 50 50 poly (l-lactide-co-ε-capro-lactone) scaffold (50PLC) were tested as a scaffold for rat costochondral resting zone chondrocytes in comparison with a type I collagen sponge scaffold (collagen scaffold).
The resting zone stain also transformed from purple to blue.
The region nearest to the end of the bone is the outermost growth plate zone or resting zone.
The proliferative zone of the growth plate lies adjacent to the resting zone and is populated with actively dividing chondrocytes arranged in characteristic columns of disc-shaped cells.
In the control growth plate, Slc39a14 was expressed from the resting zone (RZ) to the prehypertrophic zone (pHZ), with relatively high abundance in the proliferative zone (PZ) and little in the hypertrophic zone (HZ) (Figure 3B and C, top panels).
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The Nppc −/− mice had narrowed growth plates compared with Nppc +/+ with the heights of the proliferative and hypertrophic zones markedly reduced with no differences in the resting zones.
There's a rest zone in the Mall and entertainment en route, including demonstrations of unusual and vintage bikes, pedal-powered sound systems, mobile jugglers and the graceful cycling angels.
Among the resting, proliferative, hypertrophic zones, and bone area, the proliferative zone was elongated while the hypertrophic zone was normal in the C/EBPβ−/− limb (Figure 2B).
The percentage of cells showing increased expression of AR is increased in resting and hypertrophic zones compared to the proliferative zone, suggesting that signaling through AR might be used during normal chondrocyte differentiation [ 36, 59].
Overall, these data show that mutant protein retention in the ER of resting and proliferative zone chondrocytes is sufficient to cause disrupted bone growth.
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