Sentence examples for resting microglia from inspiring English sources

In healthy conditions, resting microglia and astrocytes are predominant and are important to maintain several different brain functions.

During cerebral ischemia-reperfusion, significant amounts of oxygen free radicals are generated, and the resting microglia in brain is activated and developed macrophage-like abilities, including phagocytosis and inflammatory responses (Ekdahl et al., 2009).

The morphology of resting microglia in the contralateral side was shown in the inset (Figure 8Ad).

The receptor shows robust expression in resting microglia which is reduced after microglial activation.

However, under normal conditions GSK3β in resting microglia is mostly in its less activated, serine-9-phosphorylated state.

Calcium binding adaptor protein 1, IBA-1 is expressed by resting microglia and is upregulated when these cells are activated [27].

Our results demonstrate that neurotransmission plays an endogenous role in regulating the morphology and behavior of "resting" microglia in the retina.

Leukocyte gates were set within the forward and side scatter profiles to exclude resting microglia cells in the spinal cord preparations.

Similarly, the morphology and motility of "resting" microglia are also dynamically influenced by extracellular signals such as ATP and chemokines arising from other surrounding cells [1], [4].

In this study, we address the hypothesis that ionotropic neurotransmission in the CNS serves as a rapid signal that regulates the morphology and dynamism of "resting" microglia.

Collectively, our findings indicate that resting microglia morphology and behavior are not controlled solely by cell-autonomous mechanisms but are instead regulated by different forms of neurotransmission.