In animals treated with sCPR, compressions were delivered unsynchronized with the simultaneously restarted mechanical ventilation, with equal compression relaxation intervals (that is, a 50% duty cycle) and a compression depth of 25% of the chest diameter.
Immediately after tracheal intubation, mechanical pressure controlled ventilation was restarted at the same ventilator settings.
Immediately after tracheal intubation, ventilation was restarted at the same ventilator settings and continued for 150 seconds.
Therefore, in this study, in order to avoid the influence of apnea, HRV data from the start of laryngoscopy until 30 seconds after the restart of ventilation were excluded, since HRV data are calculated from the RRIs for 30 seconds in the MemCalc™ system.
After 12 min of asphyxia, mechanical ventilation was restarted and CPB was started.
Brain temperature was maintained at 37.5 ± 0.5 °C and rectal temperature is decreased to 28 ± 0.5 °C during CA. Mechanical ventilation was restarted 30 seconds before CPR and CPR, chest compression and epinephrine administration, was initiated at 8 minutes after CA onset.
When no chest excursions were visible despite high inspiratory pressures, endotracheal tube malposition was assumed and bag-mask ventilation was restarted.
Simultaneously with the start of the pLVAD, ventilation was restarted with an inspired oxygen fraction (FiO2) of 1.0, blended with either 20 ppm of iNO or nitrogen, before animals received a bolus dose of 30 μg/kg adrenaline and Ringer's solution at a rate of 100 mL/minute.
"Now is the time to discuss things like elective ventilation, the possibility of retrieving hearts from newborns aged under three months and restarting hearts from people who have experienced circulatory death," Holt says.
