Sentence examples for rest function from inspiring English sources
Early embryonic lethality, coincident with the onset of neurogenesis, precluded analysis of REST function in Rest GT/GT neural progenitors.
Using this REST gene signature we predict that REST function is enhanced in advanced glioblastoma.
For instance, rather than solely focusing on lowering amyloid beta levels, as clinical trials have done so far without great success, Yankner imagines trying to target REST with drugs such as lithium, which his lab has shown can boost REST function.
In development, loss of REST function is an integral step in NSC differentiation, and inappropriate maintenance of REST function has been found to prevent differentiation of NSC into neurons [ 4- 6].
"The prevention of REST from getting to the nucleus may be the earliest phase in the loss of REST function.
This analysis confirms the statistically significant down-regulation of REST target genes in gliomas with respect to non-neoplastic tissue, suggesting an increase in REST function in the tumors.
Mr. Dutka came up with what he called a partial-perimeter solution: two-thirds of the room is dedicated to Mr. Unkrich's work space, so he can reach almost everything he needs without getting up; the rest functions as a den.
For each chemical, its basic structure and physicochemical property information was extracted from PubChem Compound database using PUG REST functions from PubChem [31].
REST functions as a modular scaffold for dynamic recruitment of epigenetic regulatory factors including its primary cofactor, the corepressor for element-1-silencing transcription factor (CoREST), to genomic loci that contain the repressor element-1 (RE1) binding motif.
This led to the identification of shared downstream targets, including NeuroD4, capable of neuronal reprogramming of fibroblasts and human astrocytes, as well as mechanistic insight into how the repressor REST functions as a barrier in direct neuronal reprogramming.
Consequently, the purpose of this study was to quantitatively determine the distribution of MBF in left ventricular regions with chronically impaired resting function but preserved viability in a large population of animals with single-vessel coronary stenosis in an attempt to further elucidate the mechanism(s) responsible for chronic, reversible myocardial dysfunction.
