Cardiac CT has the potential to offer comprehensive infarct detection by assessing regional wall motion abnormalities (RWMAs), rest perfusion defects (RPDs), and delayed contrast enhancement (DCE).
Close to (nu approx 0.21) there is a sharp fall to a point in which around half the population is cooperating and the rest is defecting.
REST-null defects in cell adhesion may be the cause of its phenotypic effects on Nestin+ NSC production and neuronal differentiation, because cell adhesion defects caused aberrant NSC and neuron development [20] [21].
Indeed, various studies have shown that the presence of severe resting perfusion defects, as assessed with GMPS, limits the response to CRT [ 15– 17].
F-FDG PET is often combined with a perfusion scan and ECG gating to rule out coronary artery disease or to identify resting perfusion defects suggestive of inflammation-induced tissue damage [ 51].
At randomization, SPECT revealed perfusion defects at rest in 22 (36.7%) patients and exercise-induced defects in 8 (13.3%), whereas MDCT revealed coronary calcifications in 15 subjects (25%).
These data suggest that the defect might rest in the priming of naïve T cells.
No perfusion defect at rest was detected by visual analysis.
This distribution and lack of pain at rest argues against osteochondral defect as well as avascular necrosis as an etiology.
One study compared stress and rest DECT for the detection of myocardial perfusion defects, and the results indicate that stress DECT has superior performance for the detection of perfusion defects compared with rest DECT with CMR as the reference standard [ 57].
