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Terminal differentiation of NK cells is crucial in maintaining broad responsiveness to pathogens and discriminating normal cells from cells in distress.
Innate immune responsiveness to pathogens is usually mediated by pattern recognition receptors (PRRs).
Curiously, plants over-expressing END are more sensitive to salt and drought stresses, although their responsiveness to pathogens has not been evaluated [ 68].
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Finally, the OsCPK18 and OsCPK4 promoters harbor multiple stress-related cis-acting elements, including elements that are known to confer responsiveness to pathogen-regulated genes.
It was shown that PCV2 infection of plasmacytoid DCs impairs the induction of interferon-α and tumor necrosis factor-α, which silences responsiveness to pathogen-associated recognition signals by compromising immune defense development against other pathogens.
By investigating effectors altering LPS responsiveness, this data may be applicable to finding variations within a population in relation to variation in phenotypic response to pathogens.
Marshall, J. S. Mast-cell responses to pathogens.
These results indicate that the SlSR genes are highly responsive to pathogen infection but the responsiveness of these SlSR genes may be a side effect caused by pathogen infection but not a true reflection for their function in disease resistance.
While no transcriptional modulation is strictly required for a R gene to be considered a candidate R gene (transcription of many R genes is not responsive to pathogen infection) several active R genes show moderate level of pathogen responsiveness in terms of transcription (e.g. 30% induction or more over controls), e.g. Xa1, Xa27 [ 49, 50].
The fish intestine has multiple functions which will be the first to respond to changes in nutritional intake; particularly digestion and absorption of nutrients and immune responsiveness to ingested pathogens, antigens and new antigens generated by the gut flora via gut associated lymphoid tissue [ 36].
In contrast, and as recently shown, AtCRT3 is associated with immune responses, and is essential for responsiveness to the bacterial Pathogen-Associated Molecular Pattern (PAMP) elf18, derived from elongation factor (EF -Tu.
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