Sentence examples for responsiveness to further from inspiring English sources

Continual or repeated stimulation of receptors by agonists usually leads to reduced responsiveness to further agonist challenge.

Exposure to stress early in life or to traumatic, unpredictable stress at any age has been shown to permanently increase an individual's responsiveness to further stress and reduce the ability to cope with aversive events (Lupien et al. 2009).

Continual or repeated agonist stimulation of GPCRs usually leads to reduced responsiveness to further agonist stimulation (25, 34), through the process of receptor desensitization, which has been shown to protect cells from the adverse effects of overstimulation and inappropriate GPCR signal transduction.

To confirm the HIF-1α-dependent regulation of 5-FU responsiveness and to further characterize the contribution of p53, we examined a second human gastric cancer cell line (MKN28), which carries a missense mutation in TP53 at codon 251.

As IPF fibroblasts already show reduced PDGFRα level and subsequent reduced responsiveness to PDGF-AA, further neutralization of PDGF-AA did not impact their response to epithelial injury.

Since infection is a leading cause of death for SLE patients [50], it is possible that a prolonged state of reduced responsiveness to IFNα may further compromise a patient's ability to fight infection.

If so, identifying such binding site polymorphisms that could predict the extent of responsiveness to TBA deserves further studies.

The responsiveness to PaCO2 is further decreased by coadministered sedatives or other anesthetic agents including phenothiazines [ 24], such as acepromazine.

Decreased responsiveness to progesterone is further substantiated by Bulun et al. [ 17] which showed decreased responsiveness of endometriotic stromal cells to progesterone by measuring the levels of prolactin mRNA, which is normally induced by progesterone.

Finally, 3 clock genes Per2, Cry1 and Bmal1 reported to be involved in circadian corticosteroids biosynthesis or adrenal responsiveness to ACTH were further investigated by quantitative real-time PCR.

In other words, item responsiveness to pain adds to further item reduction and refinement of a scale.