Numerous recent nanoscale drug delivery systems utilize responsiveness to biological stimuli to control drug biodistribution in vivo.
Thus, in human embryonic kidney-derived (HEK293) cells expressing Δ774 838-deleted CaMKII phosphorylation sites (Woo et al., 2008) or S502A/T704I mutants of TRPV1, capsaicin does not evoke a current, which suggests that phosphorylation by CaMKII is required to control the responsiveness of TRPV1 to the ligand (Jung et al., 2004).
Due to their natural immunosuppressive abilities, Treg have emerged in recent years as a viable alternative to control immune responsiveness to transplanted allogeneic cells and tissues (18).
Previously, we showed that treatment with the Rho-kinase inhibitor Y-27632 was able to control airway responsiveness, inflammation, remodeling, and oxidative stress in an animal model of asthma, suggesting that this drug is beneficial in asthma.
Administration of GO at the time of OVA sensitization (GO/SENT) significantly increased airway responsiveness to methacholine as compared to control (PBS) and OVA-only treated mice (OVA/ALL) up to 2.5-fold (p < 0.05, Figure 2 ).
This scale assesses three factors in the same way as the one proposed by the American Medical Association [ 24]: level of bronchial caliber, degree of bronchial responsiveness, and need for medication to control asthma [ 25].
The fragment contains a VDRE, a GAGA DNA motif, which is suggested to control the 1 α,25(OH)2D3 responsiveness of the rat osteocalcin gene [ 17, 18], as well as a TATA box.
The second argument comes from studies demonstrating that administration of exogenous angiotensin II caused a restoration of tubuloglomerular feedback (TGF) responsiveness to 71% of control in heterozygous and to 62% of control in homozygous ACE null mice.
Cancer develops when the damaged cell's ability to commit suicide is impaired or when the cell loses responsiveness to normal growth control.
GABAergic interneurons are crucial to controlling the excitability and responsiveness of cortical circuitry.
