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Controversy and lawsuits may have jeopardized the future of one of the most promising of these startups, Renaissance RX, whose business model revolved around determining patients' genetic responsiveness to certain medications, based on the results of DNA cheek swabs.
It has been reported that 24% of patients suffer from lack of responsiveness to certain DMARDs and a further 25% may stop responding after an initial period of response.
The lack of responsiveness to certain disorders, susceptibility to infections and resistance in long-term use has increased the search for alternative therapeutic agents.
On the other hand, biomarker loci that display high specificity yet lower sensitivity are candidates for potential applications aimed at sub-classifying tumors by disease prognosis or responsiveness to certain therapies.
The phylogenetic distance to the classical CB receptors and its pharmacological responsiveness to certain cannabinoids suggests that GPR55 may constitute a novel class of cannabinoid receptors.
One microarray-based transcriptional profiling assay is currently approved by the FDA for predicting responsiveness to certain therapeutic interventions for breast cancer and several others are under development [ 24].
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Hence, despite similar accuracy, females during the second half of the menstrual cycle demonstrate faster responsiveness and reactivity to certain emotionally negative stimuli.
In several cell types, there was a decrease in responsiveness to stimulation by certain cytokines (Fig. 2A).
However, because we are such an out-bred species, immunological responsiveness to any given vaccine is certain to exhibit a high level of inter-individual variation that will impact upon the efficacy, reversibility and feasibility of the approach.
The potential mechanisms by which BRAF mutations might predispose PTCs to have a more aggressive course and/or poor responsiveness to standard therapies are not certain.
However, the responsiveness of macaque APCs to certain TLR ligands partially differed from that of human in terms of phenotype differentiation and cytokine production.
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