Sentence examples for responsiveness target from inspiring English sources

Moreover, changes in CVP in response to fluid challenge tests have been used to predict volume responsiveness (target 8 to 12 cmH2O) [ 13].

The mutual interplay between excitatory feedback and mutual inhibition leads to increased responsiveness to target object detection and a decrease in background response [23].

The pure anti-estrogen ICI also rapidly degrades the ER via the ubiquitin-proteasome pathway and thus abolishes the estrogen responsiveness of target cells [4], [10].

These roles necessitate precise control both of ligand expression and the responsiveness of target cells, neither of which is well understood.

Insulin resistance is defined as the decreased responsiveness of target tissues to ordinary levels of insulin and plays a central role in the development of metabolic disorders such as type 2 diabetes, hypertension, and dyslipidemia [1], [2].

Oxygen tension also regulates the responsiveness of target cells to exosomes.

Insulin resistance is a decreased responsiveness of target tissues - skeletal and myocardial myocytes, hepatocytes, and adipocytes - to normal levels of circulating insulin (Setsi 2006).

Promoter methylation and histone deacetylation, in part, explained the lack of retinoid responsiveness of target genes in some RA-resistant cells.

Furthermore, it has been reported that use of artificially modified antigen receptors resulted in the incidence of adverse events including deaths due to unexpected responsiveness to target antigens or similar antigens expressed in normal tissue.

AKRs convert DHT, a preferred substrate, to the less active androgen 3α-androstanediol, thereby regulating steroid responsiveness in target tissues [ 13] such that variation in AKR1C activity could affect nipple development in the pig.

Pro-inflammatory cytokines and their receptors are known to antagonize the anabolic effects of insulin-like growth factor (IGF) 1 by reducing its synthesis and by a reduction of the responsiveness of target tissue to IGF-1 stimulation [ 30].