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Another important issue, particularly for instruments of this type, is its stability versus responsiveness over time and across situations.
Including these items in the ADAS-cog can hurt its performance in terms of external responsiveness over time.
Sensitivity and specificity were assessed using Area under the Receiver Operating Curve (AUC) and responsiveness over time using effect sizes (ES).
Currently we are evaluating the VISA-A-S questionnaires responsiveness over time in a randomized treatment study for patients with Achilles tendinopathy.
Further studies could also try to examine the stability of KINDL-R self reports and parent proxy reports over time and also the responsiveness over time.
We are still in the process of refining what the appropriate outcome measures should be for rehabilitation studies, their responsiveness over time, and ability to capture specific morbidities.
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Key instrument properties that are important when HRQOL measurement is employed at the individual patient level include high internal consistency reliability (e.g., alpha ~.90) and documented responsiveness to change over time as a result of treatment [ 77].
Although patients with COPD are known to change their responsiveness to treatment over time, individual heterogeneity in response to treatment was not examined during this study, which may be viewed as a limitation.
A longitudinal investigation of participant responsiveness could have given us insight in the way in which responsiveness developed throughout the intervention; in addition, it could have enhanced our understanding of the influence of responsiveness on adherence over time.
However, its reliability and validity for use in longitudinal studies and its responsiveness to change over time has not yet been assessed.
In addition, the measurement properties of the questionnaires, including internal consistency reliability, test-retest reliability, construct validity, known groups validity, responsiveness to change over time, and an estimation of what change is clinically meaningful should be evaluated.
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