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Our data additionally confirm responsiveness of cells with FOP ACVR1 mutations to both BMP and Activin A ligands.
Several mechanisms to explain the responsiveness of cells to ultra-low doses and the similarity as inversion of drug effects, have again been suggested in the framework of hormesis and modern paradoxical pharmacology.
Unlike AF cells, however, NP cell gene expression was not stimulated by any conditioned medium, suggesting that differences exist in the responsiveness of cells of notochordal (NP) and fibrocartilaginous (AF) phenotypes.
Hydrogen peroxide (H2O2) plays a pivotal role in determining the responsiveness of cells to stress.
An additional level of regulation of hBD-2 expression is the responsiveness of cells to pro-inflammatory cytokines.
As we show here for SVZ glial precursors, these differences in the effects of TGFß1 could be due to varied responsiveness of cells at different stages of differentiation.
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They have biological activities that act to influence the function and responsiveness of cell membranes and tissue metabolism, to hormonal and other signals.
KRR initially demonstrated the responsiveness of cell lines to TGF-β1 and IL-6.
Can systems models that accurately predict the responsiveness of cell lines to targeted apoptosis inducers and sensitisers be validated clinically?
These findings suggest that sCD14 released in response to high dose LPS regulates LPS-responsiveness of cells secreting TNF, but not the cells responsible for the attraction of PMNs.
Induction of CYP1A1 and CYP1B1 are prototypical markers of AH-responsiveness of cells to TCDD and other AHR agonists.
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