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Responsiveness is expected to be within weeks, including symptomatic improvement, reductions in the size of masses or organ enlargement, improvement in organ function, and usually a decrease in IgG4 serum levels.
Responsiveness is expected to impact positively on health outcomes [ 5], since it will lower the threshold to seek help early.
Higher fluxes of maltose production and transport into the cytosol imply increased dependence of the model system on any reaction that consumes cytosolic maltose to achieve a steady state maltose concentration, so increased DPE2 responsiveness is expected.
Finally, stochasticity in levels of gene expression and responsiveness is expected to mark any apparently homogenous population of cells including T cells [ 24- 29], although it is difficult to distinguish between subset-dependent variations and true statistical noise.
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Younger animals' superior responsiveness to oxidative insult is expected based on their antioxidant capacities: for example, steady-state mRNA levels for the ROS detoxification enzymes glutathione S-transferase and superoxide dismutases were elevated in larval but not adult worms subjected to acute paraquat exposure [ 75].
It is expected that responsiveness will impact positively on mental health outcomes, since it will decrease the relapse rate and enhance patient compliance [ 8].
Lack of responsiveness to added Hh-ligand is expected considering the very low levels of SMO expression observed in SUM149 cells (data not shown).
Moreover, decreased HCN channel activity increased the steady-state Rin of fusiform cells, which is expected to enhance responsiveness of fusiform cells to synaptic inputs.
The dominant-negative receptor approach is expected to diminish responsiveness to all three TGF-β isoforms, and to reduce or eliminate downstream signaling through all Smad transduction components.
Control of the 'purchasing power' is expected to drive market responsiveness [ 12][p.8].
This receptor downregulation in the tumours is expected to result in a reduced responsiveness towards angiogenic stimuli.
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