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Despite recent advances in this field, the available drugs are not devoid of side effects and a large subset of CD patients do not respond or undergo loss of responsiveness in the course of their disease [ 162].
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Various cleavable peptide units, differing either in their thrombin turnover rates or in their responsiveness to factors activated earlier in the course of blood coagulation, were used for the formation of the biohybrid materials.
We initially intended to measure airway responsiveness using the provocation dose of AMP required to reduce FEV1 by 20% (PD20AMP), but found in the course of recruiting for the study that very few volunteers demonstrated this degree of airway responsiveness.
In the course of Rhet.
Alternatively, the first wave OPCs could be lost in the course of a (not yet demonstrated) oligodendrocyte turnover, or as a result of changes in the availability/responsiveness to growth and differentiation factors.
Several immunohistochemical studies have been undertaken to elucidate the coexpression profile of HER receptors in breast cancer, providing preliminary data on other HER receptors besides HER2, which may have an impact on the course of disease and therapy responsiveness in breast cancer patients [ 18- 20].
It is concluded that various hepatomas have elevated responsiveness to PGE1 and PGE2 as well as to adrenalin, but the course of change in the tissues' ability to respond to these agents during carcinogenesis is very different.
The present study further establishes the reliability and validity of the DLQI and its responsiveness to change in the clinical status of patients over the course of a 12-week clinical trial, confirming previous findings [ 28].
The four measures also demonstrated significant responsiveness to change in underlying clinical status of the patients over the course of the trial, as measured by the independently assessed clinical outcomes.
Our data confirm the negative association between the changes in the levels of resilience with the course of fibromyalgia syndrome measured by FIQ scores and constitute indirect evidence of responsiveness of 10-item CD-RISC.
The pain, strictly correlated with the course of gastroenteritis, was mainly localised in the central abdomen, without radiation and with a good responsiveness to antispatic drugs.
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