However, we cannot exclude the possibility that wound healing factors might permanently or temporarily change the responsiveness to factors present in tissue that could affect the metastatic propensity of the cells or that long term exposure of tumor cells to wound healing processes per se could result in permanent cellular changes.
Various cleavable peptide units, differing either in their thrombin turnover rates or in their responsiveness to factors activated earlier in the course of blood coagulation, were used for the formation of the biohybrid materials.
The antagonist Ang-2 is known to downregulate Tie2 signaling, thereby preparing vascular endothelial cells for enhanced responsiveness to factors that cause destabilization of the endothelial barrier [12].
Responsiveness, health factors and context (management of condition by several physiotherapists) had a similar predictive ability on variations between physiotherapists (2 to 3%).
Adaptating HSEs to study wound reepithelization has demonstrated several key responses including cell proliferation, migration, differentiation, growth factor responsiveness and protein expression that mimic the response to wounding seen in human skin [7].
This heterogeneity is detectable at different levels, that is, markers of cell activation, gene expression, responsiveness to growth factors, and antigen composition, and differentiates the behaviour between micro- and macrovascular ECs, as well as between cells isolated from different organs and from different vascular districts of the same organ.
Cortical and spinal cord derived neural stem cells displayed similar growth factor responsiveness throughout embryonic development (Figure 1).
Several reports indicate differences in growth factor responsiveness between rodent and hNSCs as regard to oligodendroglial production [2], [35], [36].
Introducing intracellular portions of Frizzled receptors into the Ste2p backbone resulted in the generation of constitutively active receptor chimeras that retained mating factor responsiveness.
This property can be used to define macropinocytosis along with the size of the organelle and responsiveness to growth factor stimulation [3].
In contrast, molecules able to promote proliferation, survival and maturation of rodent OPC from NSCs [34] are not similarly effective on hNSCs, pointing to inter-species differences in growth factor responsiveness [2], [35], [36].
