The number of repetitions reaching the responsiveness criterion expected by chance was determined from the 10 samples of spontaneous activity collected during the 1.55 s preceding each stimulus sequence and corresponded to the maximum number of activations observed in the same bin.
Then, each of the 10 stimulus repetitions was tested individually and the same bin (with respect to the stimulus) had to reach the responsiveness criterion independently over a significantly higher number of repetitions than expected by chance (binomial test at the 0.05 level of significance) to be considered as a reliable response to the stimulus.
The CMIs we used have all undergone various degrees of validation (responsiveness, criterion validation), with the CBPI and the LOAD being the most evaluated and considered the most valid [ 26- 29].
The response and responsiveness criteria were applied to each patient, and for each segment the mean dose, and observed and predicted HV was calculated.
In their review on change in health-related quality of life, Crosby et al. recommend two major approaches of responsiveness: Criterion-referenced change (or anchor-based methods) and precision-referenced change (or distribution-based methods).
The observed differences in WPS score changes and the effect sizes seen for clinical responders and nonresponders, and the similarities in the responsiveness of the WPS questions when using different response criteria, support the responsiveness and reliability of the WPS in patients with PsA.
The responsiveness and reliability of the WPS for use in axSpA has been confirmed not only by the differences in the mean changes in WPS scores but also by the effect sizes seen for responders and nonresponders and the similarities in responsiveness when using different response criteria.
To assess responsiveness, some criterion is needed to identify whether patients have changed (either improved or worsened) over time.
The Effect Size Index (distribution method)(ESI) and Guyatt's Responsiveness Index (criterion method)(GRI), were selected a priori to calculate measurement responsiveness of the DEMMI, HABAM and BI.
Despite the strong psychometric properties of the SUNS several important properties have not been assessed, including, convergent validity, discriminant validity (known-groups validity), test-retest reliability at the domain level, floor and ceiling effects, responsiveness and criterion validity.
Therefore, here we performed a preliminary analysis to determine the reliabilityf, responsiveness and criterion validitiesg for canine pain assessment in a one-way crossover clinical trial in naturally occurring OA in dogs that were fed with two successive diets (control and therapeutic) during a 90-day period.
