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HepG2 cells became responsive to the effect of MKL1/2 knockdown on cell proliferation only after depletion of DLC1 expression.
Knockdown of MKL1/2 in HepG2 DLC1 shRNA expressing cells abolished the pro-proliferative effect of DLC1 knockdown (Fig 1H), demonstrating that DLC1 deficiency renders HepG2 cells responsive to the effect of MKL1/2 knockdown on cell proliferation.
SM/J individuals tend to be more responsive to the effect of a high-fat diet in relation to body weight, fat depot weight, organ weight, basal glucose levels, and triglyceride levels [ 23, 24].
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A blood test to check testosterone doesn't usually give you useful information because you can have normal blood levels but become less responsive to the effects of testosterone.
Persuasion swing states will be relatively more responsive to the effects of the campaign and changes in the national environment, including economic conditions.
The EVI, communities of small mammals, and abiotic and biotic water conditions were responsive to the effects of hurricanes and can thus be useful for a long-term ecological monitoring program at the basin scale.
In light of considerable advances in molecular and radiobiological characterisation of GBM, it is possible to hypothesize that certain subsets might be more responsive to the effects of radiotherapy, and trials enriched with such patients might in fact provide a basis for testing a possible survival advantage with higher doses of radiotherapy.
One may speculate that R mice are more responsive to the effects of cocaine, including the effect on this aspect of behaviour.
We report that lupus MDDCS behave similarly to normal MDDCs and are responsive to the effects of vitamin D in vitro.
The fact that a large number of genes are responsive to the effects of TSA and L-methionine implies that the epigenetic regulation of gene expression as a function of maternal care may be extensive.
This suggests that mitochondria may be less responsive to the effects of glucocorticoids and thus, one purpose of the present study was to determine whether synthesis rate of mitochondrial proteins varies from other muscle protein fractions in glucocorticoid-treated rats.
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