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Results from this study show that the immunomodulated B16 murine melanoma is responsive to radiation therapy alone and that this responsiveness is enhanced by the addition of adjuvant regional hyperthermia.
Germinomas have a good prognosis, with a 5-year survival rate of at least 90%% and are highly responsive to radiation therapy [9, 18, 21].
The egr-1 was the first promoter described more than 2 decades ago to be responsive to radiation [27, 60, 61].
In another study, TUBO tumors in SCID mice were found to be less responsive to radiation than TUBO tumors in immunocompetent BALB/c mice [9].
Notably, the INPP4A gene was not responsive to radiation in either parental HEp-2 or RR-HEp-2 cells.
These studies revealed that genes involved in cellular structural integrity, immune functions, cell cycle control, and apoptosis were more responsive to radiation.
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To select a potent radiation inducible promoter in the context of brain tumors and to investigate if CArG radio responsive motifs or other elements in the promoter nucleotide sequences can correlate to its response to radiation.
The 100 genes with the most significant response to radiation in patients were identified and analyzed for differential patterns of expression in the radiation-responsive versus nonresponsive cell lines.
Treatment of Balb/MK2 mouse keratinocytes with UVB radiation resulted in increased levels of p53 protein and its target gene, p21 demonstrating that Balb/MK2 keratinocytes are responsive to UVB radiation.
Vegetation growth enhances heat transfer and increases the height of the Earth's boundary layer, the lowest part of the atmosphere that is highly responsive to surface radiation.
MPM is extremely resistant to most chemotherapy regimens examined and not responsive primarily to radiation therapy in general [ 3, 4].
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