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We designed new terpolymers responsive to pH, temperature, and metal ions.
Dynamic light scattering (DLS) showed that the polymeric micelles had a size of 60 nm at physiological pH and were responsive to pH.
The N,S-CQDs are responsive to pH and exhibit color-switchable fluorescence performance between alkaline and acidic environments with good reversibility.
The biotin-functionalized unimolecular micelles were responsive to pH and further utilized in encapsulation and release of PPa for photodynamic therapy (PDT).
The results show that OmpG-16S is responsive to pH change as indicated by the Amide I band shift upon a switch from acidic to neutral pH.
In the Raman spectroscopic test, these pH probes were responsive to pH changes from 6 to 8, and when inserted into Chinese hamster ovary (CHO) cells, they provided accurate intracellular pH information.
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As has been reported, owing to its pH-responsive property, P2VP can alter its wettability as well as its conformation by protonation and deprotonation of its pyridyl groups in response to pH changes, 26, 28, 29 and thus the grafted BCP endows the core/shell-structured particles with a pH-responsive property.
In this study, viable glioma cells recovered 3 h after Ph-PDT were considered as relatively resistant/less responsive to Ph-PDT.
Although many types of stimuli have been extensively studied as drug carriers, including their responsive abilities to pH, temperature, redox, light, ionic strength, enzyme and so forth, a variety of the researches have focused on utilizing pH-responsive polymeric micelles [11 15].
It is possible to control their chemical functionality to make them environmentally responsive, for example to pH or temperature.
At the lower pH, HL-60 cell fluorescence increased substantially, indicating that the probe associated with the acidified cells is in an acidic environment; therefore the probe appears to be responsive to low pH such as found inside a low-pH lysosome.
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