Rather our focus is on how communication can be used to change a corporate actor's operations so it becomes more responsive to its key stakeholders in terms of CSR and sustainability issues, used to create more sustainable supply chains, and used to help corporate actors become key partners in creating resilient communities.
Thus it is possible to study for the first time the genes that are responsive to these two key cytokines on a transcriptome wide scale in a lower vertebrate.
Our attempts to reverse-engineer the very complex time-dependent progression of regulated transcripts resulted in the conclusion that the early phase is characterised by regulation of genes that may be responsive to a few key transcription factors, such as Mtf1, Jun, Stat1, Ppara, and Gata3.
Analysis of transcription factor binding sites in the regulatory region of genes exhibiting altered expression resolved initial regulation of genes responsive to a few key transcription factors (e.g. Mtf1, Jun, Stat1, Ppara, Gata3) followed by hedgehog and bone morphogenic protein signalling, possibly leading to stem cell differentiation.
In this study, we reformulate unfractionated heparin (UFH), the prototypical clinical anticoagulant, into a self-assembled nanocomplex that is responsive to thrombin, a key protease of the coagulation cascade, by leveraging the charge interaction of PEGylated cationic peptides composed of thrombin-cleavable substrates with naturally anionic heparin.
An alternate explanation for this observation might lay in the fact that long term cell lines do not assemble the highly invasive phenotype in vivo that is observed clinically [ 45] and therefore might not be as responsive to inhibition of key signaling molecules.
The findings support the need for the development of a municipal action plan for key populations in the FCT based on the identified priorities and the review of the national HIV/AIDS strategy to be more responsive to the needs of key populations.
Successful PD programs include enough flexibility so that they are relevant and responsive to the local context, allow key stakeholders to play a role in decision-making, and encourage participants to take ownership of their learning (Coburn 2003; Darling-Hammond and McLaughlin 1995).
