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According to a study published in Nature in 2001, taking one dose of cocaine may "throw open a window of vulnerability" during which the brain is acutely responsive to further doses.
Importantly the FGF4/Erk signal does not specify lineage but renders ES cells responsive to further inductive signals.
The data also suggest that, in obese individuals, mitochondria are already uncoupled or damaged and less responsive to further fatty acid-induced uncoupling [ 25].
In GLUTag cells we showed previously that amino acid transport induced a small Na+-dependent inward current of ∼3 pA/cell, which increased L cell excitability and firing rate (9), potentially also making the cell more responsive to further stimuli.
Although metastatic breast cancer (MBC) may be responsive to further treatment, it is incurable, and so improving the quality of life (QoL), not merely the length of life, is an important parameter of benefit.
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Considering the possibility that the effect of such ECM treatment could render DC un-responsive to further stimulation, we studied the maturation state of these cells after stimulation with LPS and CD40L.
When a patient was identified as stroke volume responsive to fluid, further 250 ml boluses of fluid were administered until a plateau value was achieved.
However, we saw little evidence of floor effects, which implies that the measure would be responsive to detecting further deterioration in a parent's HRQL and family functioning.
The finding that a number of symptoms used at this time in common UC disease activity indices are rarely present in UC flares and/or are less responsive to change furthers the point that by using existing measures we may not be optimally assessing a patient's UC activity.
The biotin-functionalized unimolecular micelles were responsive to pH and further utilized in encapsulation and release of PPa for photodynamic therapy (PDT).
The findings provide evidence that aripiprazole augmentation of clozapine treatment is well-tolerated and may be of benefit for patients who are partially responsive to clozapine monotherapy; further double-blind, placebo-controlled trials in a larger number of patients are required to evaluate the therapeutic potential of aripiprazole augmentation of clozapine.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com