In this study, we intend to experimentally indentify miRNAs and siRNAs in the tobacco genome, especially small RNAs responsive to damages through high-throughput sequencing of small RNA populations from wounding or topping treated tobacco plants.
Many proteins are also directly responsive to DNA damage, including those responsible for DNA repair.
Mr. Bloomberg, an independent, offered a much kinder assessment, saying the federal government had been very responsive to the damage wrought by Hurricane Sandy.
To further determine whether activation of ORGs was responsive to tissue damage or to genetically regulated activation of osmosensitive signaling pathways, we performed microarray analysis of five osmotic stress resistant (osr) mutants grown under isotonic conditions.
Although the epidermal αβ T cells identified in B6 δ−/− mice are not responsive to keratinocyte damage, they do express the activation markers CD69, CD25 and CD103 similar to γδ T cells in the skin [37].
Responsive to DNA damage, 14-3-3σ expressinducedinduced in a p53-dependent manner [ 10- 12].
It may indicate that ANKRD26 is responsive to DNA damage [ 45], pericentromeric cohesin and condensing [ 46], and even centromere formation.
In vivo, sumoylated PARP-1 is associated with chromatin, but the modification is not responsive to DNA damage and is not affected by PARP-1 catalytic activity.
The following experiments tested whether exogenous E+P primes p53 to be more responsive to DNA damage and whether these pathways confer resistance to mammary tumors in a mouse model of Li-Fraumeni syndrome.
We examined this hypothesis with respect to the DDR and report our findings from a large-scale antibody-based screen for histone modifications that are responsive to DNA damage.
