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In most responsive tissues, the response to ecdysone triggers a transcriptional cascade of NR responses (Ashburner 1972; Fahrbach et al. 2012).
Whole embryos are a mixture of cell types, which might obscure an abnormal response to Wnt in specific responsive tissues.
Therefore, the proliferative/antiproliferative responses caused by BPS can happen in multiple responsive tissues.
Both these tumors are originating from estrogen responsive tissues and are known to share hereditary genetic predisposition factors [39].
The human NR fusion proteins used also contain a new affinity tag cassette allowing the purification of receptors with bound molecules from responsive tissues.
These data suggest a role for DKK1 in the regulation of cell cycle in androgen responsive tissues, and further studies in ovary, particularly ovarian theca may confirm this.
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As mentioned, AT is responsible for the major form of crosstalk between insulin-responsive tissues.
It is expected that these assays could be applied to profile ERα isoforms in any estrogen-responsive tissues.
The results would be progressive expression and co-expression of mismatched and unresolved growth-arresting (Yin, or tumoricidal) and growth-promoting (Yang, or tumorigenic) factors in the immune-responsive tissues (e.g., epithelial-mesenchymal, stroma, vascular endothelial).
Histamine, at low circulating level was suggested as blueprint for maintaining oxidative stress that contributes to tissue necrosis or growth in immune-privileged or immune-responsive tissues and induction of neurological or autoimmune diseases or tissue growth promotion.
Interestingly, we demonstrated an excellent biocompatibility and electroactivity of the hybrid microfibers for PC12 cell culture, thus promising a flexible template for the reconstruction of electrically-responsive tissues mimicking muscle fibers or nerve networks.
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