Overall, LC-MS detected 254 (256) proteins in highly (lowly) glucose-responsive subpopulations – of which 232 (229) above limit of quantification and 90% (215) overlapping identifications (Table S2).
Alternative approaches to managing the large and heterogeneous placebo response in OAB drug trials in the future might be to develop and validate more objective endpoints for OAB trials, characterize more drug-responsive subpopulations of patients, and/or to explore different trial designs that can reduce population heterogeneity (e.g. relapse prevention).
In the NPS-responsive subpopulation of interneurons we observed effects that were comparable to those on LA projection neurons, with a persistent modulation of mEPSCs frequency in the presence of TTX.
Addition of the LXR- or PPARα-agonists exerted a much more pronounced protective effect in the low-responsive subpopulation, which is in part related to their higher palmitate toxicity but which also indicates that they can generate cytoprotective mechanisms when receiving extracellular signals.
While no interleukin-27-responsive subpopulation was identified, SCF-, FLT3L- and granulocyte colony-stimulating factor-responsive cells were observed in the diagnostic AML BM samples, although in a lower percentage (∼1%).
The V2r class of vomeronasal sensory neurons mediates the action of all MUPs, but the darcin-responsive subpopulation must have a specific, labeled-line projection to brain reward circuits.
Yet, the minor subpopulation of responsive patients had striking objective radiographic responses and shared a number of clinical/epidemiologic characteristics (adenocarcinoma histology, East Asian ethnicity, a history of never smoking cigarettes and female gender), suggesting a common molecular background (Sequist and Lynch, 2008).
Our Ca2+ imaging analysis allowed us to define different subpopulations of cold-responsive neurons based upon their -menthol and mustard oil sensitivity.
GC-D-positive neurons can be grouped into three functionally distinct subpopulations: while some are responsive to both guanylin and uroguanylin, others respond to only one or the other of these peptides [10].
This identifies CCKLPBN neurons as one neurochemically defined subpopulation of LPBN cells responsive to states of glucoprivation, in addition to other non-CCK-expressing cells.
