When we went over the Kingston Bridge, I sensed her stop fiddling for a moment; I turned and saw her hands still in her lap, her soft, responsive profile as she looked out the window reacting to the huge bright sky and sparkling water.
As described above, however, the luminal ER+ transcriptional profile is not, in general, an estrogen responsive profile.
Patients who had an HT responsive profile had a significantly decreased RFS (HR = 1.64; 95% CI: 1.035 to 2.6; P = 0.037) and OS (HR: 2.08; 95% CI: 1.21 to 3.56; P = 0.007) when compared to those with a non-responsive profile.
A HT responsive profile was associated with ERα negative disease (P = 0.0002), increased pathological grade (P = 0.003), and increased proliferation (P = 0.0002).
These mutations were commonly found in patients fitting the responsive profile observed in initial and subsequent clinical studies [ 3, 4, 10], specifically female non-smokers of Asian descent.
A 2T responsive profile was associated with ERα negative disease (P = 0.0001), increased pathological grade (P = 0.005), and increased proliferation (P = 0.001).
There was no significant difference in RFS (HR = 0.91; 95% CI: 0.585 to 1.417; P = 0.68) and OS (HR = 0.773; 95% CI: 0.470 to 1.271; P = 0.30) between patients with the 2T responsive profile when compared to those with the non-responsive profile.
According to our real time PCR analysis the silencing related genes studied here fall into three different categories: DCL4, which displayed a light responsive profile in all the cases studied including wt plants.
The benefit from GD compared to D was considerably larger in patients with a G responsive profile, and this heterogeneity was confirmed by a statistically significant test of interaction between this panel and treatment for OS.
Mice in VS(E+I) treated group showed an initial surge in BG concentration upon intraperitoneal glucose injection, followed by a quick decrease to normoglycemic level in 60 min. The glucose responsive profile in VS(E+I) group was comparable to that in the healthy mice control group.
Metabolomics is a universally applicable, comprehensive analytical approach for the identification and quantification of metabolites in a biological system, leading to description and understanding of a metabolic-responsive profile (Holmes et al., 2008; Suhre et al., 2011).
