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When we went over the Kingston Bridge, I sensed her stop fiddling for a moment; I turned and saw her hands still in her lap, her soft, responsive profile as she looked out the window reacting to the huge bright sky and sparkling water.
As described above, however, the luminal ER+ transcriptional profile is not, in general, an estrogen responsive profile.
A HT responsive profile was associated with ERα negative disease (P = 0.0002), increased pathological grade (P = 0.003), and increased proliferation (P = 0.0002).
These mutations were commonly found in patients fitting the responsive profile observed in initial and subsequent clinical studies [ 3, 4, 10], specifically female non-smokers of Asian descent.
A 2T responsive profile was associated with ERα negative disease (P = 0.0001), increased pathological grade (P = 0.005), and increased proliferation (P = 0.001).
Patients who had an HT responsive profile had a significantly decreased RFS (HR = 1.64; 95% CI: 1.035 to 2.6; P = 0.037) and OS (HR: 2.08; 95% CI: 1.21 to 3.56; P = 0.007) when compared to those with a non-responsive profile.
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Metabolomics is a universally applicable, comprehensive analytical approach for the identification and quantification of metabolites in a biological system, leading to description and understanding of a metabolic-responsive profile (Holmes et al., 2008; Suhre et al., 2011).
Consistent with the present results, stimulation of Gαi2-deficient peripheral T cells induced a hyper-responsive profile of interleukin-2, tumor necrosis factor, and interferon-gamma production [18].
Finally, analysis from tissues of wt plants showed that the mRNA levels of DCL1, DCL2 DCL3, AGO1 and RDR6 did not exhibit a light-responsive profile.
A similar wounding-responsive profile is also adopted by the S. elaeagnifolium putative DXS gene - unigene2314; its expression is even more pronounced than TPS cl7653 but it drops more drastically as the time after wounding proceeds.
Of note, all of the patients with this SCF-responsive profile were less than 60 years old and, with the exception mentioned above, they all had intermediate- or high-risk cytogenetics; six out of seven also had an early myeloid FAB classification of M1 or M2.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com