The orchestra needs more plushness in the strings, but it is a far more responsive organism than it was under Gerard Schwarz, its preceding music director.
The induction of HSPs expression is one of the common heat responsive mechanisms in all organisms [ 46- 50].
These model organisms are responsive and sensitive to various damaging factors, and their physiological manifestations allow understanding of toxicity mechanisms.
The recent identification of immune responsive genes from other organisms would eventually lead to develop a comparative species-specific immune responsive transcriptome in which this report becomes one of the first attempts.
To investigate the comparative biology of stress-responsive transcriptome at organismal level with the currently available data, we compared the CaUnigenes with previously reported stress-responsive genes from other organisms.
Reduction of the analysis criteria to heat shock and oxygen exposure, which are more likely to cause extensive protein damage, expands the list of genes to the chaperones dnaJ [tde0629], groES [tde0934], htpG [tde2480] as well as the proteases lon [tde0670] and clpB [tde2327] all of which have been found in other organisms to be responsive to the cellular accumulation misfolded proteins [30].
In order to cope with changing environmental conditions, organisms require highly responsive stress mechanisms.
Regarding MIC breakpoints, the European Committee on Antimicrobial Susceptibility Testing states that isolates with an MIC <16 µg/mL for azithromycin should be considered as wild-type organisms that are responsive to treatment (3 ).
In addition to the large number of mouse models being created with CRISPR/Cas9 technology, additional organisms have proven responsive to this method of manipulation, including traditional animal models: Drosophila melanogaster [ 73, 74], Caenorhabditis elegans [ 75, 76], Saccharomyces cerevisiae [ 77] and Dani rerio [ 78, 79].
