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Molecular mechanisms (e.g., mechanosensors) by which cells sense and respond to mechanical signals is the major challenge we are facing, since we are still far away to establish the responsive network under global mechanical stimuli.
But it also demands a highly responsive network of exchange in order to function smoothly.
However, whether ABA has a fundamental role in cold sensing and cold responsive network is unresolved.
Thus, extending our research to more candidate genes of the frost responsive network will certainly be worthwhile.
However, members of the Cbf gene family are not the only key factors in the frost responsive network [ 55, 56].
In our previous study, such enrichment was also observed for such a generally pathogen responsive network module.
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Based our WGCNA analysis results and a previous review [ 63], the representation of responsive networks regulated by metals in cyanobacteria was schemed in Figure 1.
Other examples of N-responsive NAC transcription factors include NAC4, a key regulator of a nitrate-responsive network reflected in Arabidopsis lateral root growth in response to nitrate [ 48] and PtaNAC1, found to be a central regulator of root response to low N in genetic network analysis of poplar [ 49].
We aimed to validate our in vitro data by focusing on a therapy-responsive network of patient-derived data from a previous study [ 15].
Superposing the transcriptomic data from microarray studies onto this deduced network allowed us to characterize the time- and ligand concentration-dependent activation of the PPARα-responsive network.
These clusters of interacting genes suggest co-regulatory mechanisms and may therefore lead to the discovery and/or elucidation of possible novel Pi-responsive network.
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