Domains that have been extensively explored in recent years include those with sequences inspired by, or based on, structural proteins known for their superior stimulus-responsive, mechanical, biocompatible, and structural properties.
Living cells are exquisitely responsive to mechanical cues, yet how cells produce and detect mechanical force remains poorly understood due to a lack of methods that visualize cell-generated forces at the molecular scale.
Although it would be difficult to generalize these findings to all NR formation, it is nonetheless pertinent that nuclear architecture can change in response to chromatin state and, in particular, that it is responsive to mechanical forces emanating from within the nucleus.
HSCs, like other myofibroblast-like cells, are highly responsive to mechanical cues, requiring a stiff microenvironment to become activated and therefore initiate and perpetuate fibrosis.
Notably, we observed that the levels of HIF-1α, LOX and LOX-L2 are responsive to mechanical cues independent of tamoxifen-mediated signalling.
The aim of this study was to determine whether human dental pulp-derived cells (DPC) are responsive to mechanical loading by pulsating fluid flow (PFF) upon stimulation of mineralization in vitro.
Gene expression analysis revealed that AmSesTPS1 and AmGuaiS1 were both responsive to mechanical wounding and thus can be associated to formation of agarwood sesquiterpenes.
Western blot analysis showed that the expression level of myosin light chain, claudin-5, and VE-cadherin significantly reduced under pressure elevation in control cells but not in senescent cells.AAP cells are mechano-sensitive; however, cell senescence rendered the cells less responsive to mechanical stimulus, which may have pathological consequences.
However, this species is less responsive to mechanical than to visual stimuli.
Units responsive to mechanical stimuli were categorized as MSA fibers.
