AG-MA hydrogels exhibited pH-responsive, demonstrating them to be appropriate materials for further tests as drug carriers.
The tailor-made dually responsive micelles demonstrated favorable stability in normal physiological environment and triggered rapid drug release in acidic and/or reduction environment.
Between 240 480 minutes of acclimation the majority of responsive genes demonstrated a minimal rate of change, where there is little difference in expression between the penultimate and final time-points, suggesting that the transcriptional response was essentially complete.
For example, pH-sensitive magnetic nano-complex composed of iron oxide NPs and pH-responsive ligand demonstrates effective diagnosis and therapy against colorectal cancer.
Additionally, the satisfying selectivity, good reproducibility and high consistency of dual-signal outputs of this designed dual-responsive immunosensor demonstrated the promising application in developing sensitive and accurate immunosensor for clinical test and disease diagnosis.
Transcription of several interferon-responsive genes demonstrated IFNα/β action in the brain and this was associated with a number of anti-inflammatory effects.
In an in vivo model with mice bearing A549 xenografts, the pH-responsive particles demonstrated better tumor growth inhibition as well, indicating that the interaction between the photosensitizer and tumor cell also affects the efficacy of PDT.
The CBHA-responsive genes demonstrated strong networks in Clusters E and formed TNF-α-, IFN-γ-, TP53- and cyclins/CDK specific gene networks at 6 and 24 h (Additional files 3 and 4: Figures S3 and S4).
In transdifferentiated MFB, expression of a constitutively active TGFβ receptor I, but not treatment with TGFβ1, resulted in transcriptional activation of a TGFβ responsive promoter, thereby demonstrating completely restored TGFβ signal transduction.
Smart micelles designed with responsive features have demonstrated the utility in many cases compared to controls lacking such functionality.
