Based on these findings, having used thermo-sensitive CS copolymer, CGH NPs were obtained in one-pot procedure, which could be considered as stimuli-responsive delivery system with potential biomedical applications.
The findings of the study can be utilized for the development of electro-responsive delivery systems of other drugs for the safer and effective drug delivery.
Recent developments in molecular biotechnology include antibody-mediated drug release, feedback-responsive delivery systems, carrier-mediated transport, microspheres composed of polymers and liposomes, permeabilizers, and selective delivery to localized sites and vectors.
The pH-responsive delivery systems have brought new advances in the field of functional nanodevices and might allow more accurate and controllable delivery of specific cargoes, which is expected to result in promising applications in different clinical therapies.
A model system, α-chymotrypsin (Cht) (a protease) and a cleavable peptide-chromogen (pro-drug) covalently incorporated into a hydrogel, was investigated to understand the mechanisms of covalent loading and release by enzymatic cleavage in bio-responsive delivery systems.
This article reviews recent progress in the development of carbon dioxide (CO2) bubble-generating drug carriers, including their designs and operating mechanisms; these carriers constitute an advanced class of stimuli-responsive delivery systems with considerable potential.
Recently, the pH-responsive delivery systems have attracted much attention in the research of controlled drug delivery [9 12].
These pH responsive character of the PLLm-b-P[Asp DIP ]n micelles made them as PLLm-b-P[Asp DIP ]nsive gene delivery system which may co-deliver drug and DNA simultaneously.
Herein, MSN-based dual intracellular responsive gene delivery system CMSN-A was designed and fabricated.
This study describes the design of an MSN-based carrier for use in a heat shock responsive drug delivery system.
So a non-selective redox responsive drug delivery system may result in an undesired drug release in normal cells and relevant side-effects.
