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When designing enzyme responsive delivery platforms, it is critical to understand the accessibility of the substrate to the enzyme.
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Moving to constant, lower inventory levels through frequent and responsive deliveries would reduce waste, lessen storage space requirements and reduce the risk of being out of stock.
GSH (10mM) was added to study the effect of redox-responsive delivery of nanoparticles.
Recently, the pH-responsive delivery systems have attracted much attention in the research of controlled drug delivery [9 12].
Furthermore, redox-responsive delivery of DNA drugs using disulfide-linked polymer nanovehicles was also investigated by several authors [26 29].
Finally, pH-responsive delivery of drugs in microfluidic units is also discussed and demonstrated via cell viability tests.
The findings of the study can be utilized for the development of electro-responsive delivery systems of other drugs for the safer and effective drug delivery.
This article reviews recent progress in the development of carbon dioxide (CO2) bubble-generating drug carriers, including their designs and operating mechanisms; these carriers constitute an advanced class of stimuli-responsive delivery systems with considerable potential.
Recent developments in molecular biotechnology include antibody-mediated drug release, feedback-responsive delivery systems, carrier-mediated transport, microspheres composed of polymers and liposomes, permeabilizers, and selective delivery to localized sites and vectors.
Based on these findings, having used thermo-sensitive CS copolymer, CGH NPs were obtained in one-pot procedure, which could be considered as stimuli-responsive delivery system with potential biomedical applications.
The pH-responsive delivery systems have brought new advances in the field of functional nanodevices and might allow more accurate and controllable delivery of specific cargoes, which is expected to result in promising applications in different clinical therapies.
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