Only 9 out of 14 drug dose-responsive curves are used for developing the drug combinatory synergy predictive model.
Each sample was tested in duplicate, and the standard dose-responsive curves were established using the WHO cytokine standards.
For example, preclinical data indicate that the 500 kDa and 900 kDa have nonparallel dose-responsive curves, which means that their relative performance is not consistent across a range of dose ratios and that a given unit of one toxin does not stand in a constant unit relationship to another toxin.
As is shown in the figure, the responsive characteristics curve is mainly decided by the threshold value, the slope and the limit value.
It's solid yet responsive, with curves that fit my hands, buttons in all the right places.
To explore whether expression of hormonal receptors identified a subgroup of HER-2-positive/70-gene profile low-risk tumours with a particularly favourable outcome, we separately analysed the 40 out of 168 patients (24%) with HER-2 overexpression that were highly endocrine responsive (see Kaplan Meier curves in Figure 3A).
But a study by Mr Malpezzi and Duncan Maclennan, of Glasgow University, suggests that in the medium term supply is much more responsive (ie, the supply curve is less steep) in America than in Britain, where planning regulations are stricter.
These findings are consistent with animal models of perceptual learning showing that tuning curves become narrower for the trained population of visual cortical neurons [32], and that as neurons narrow their tuning curves, smaller responsive neural populations are reflected by decreased EEG [33], [34] and fMRI [35] signals in humans.
Fluid resuscitation is performed because it is assumed that the heart is operating of the steep ascending portion of the Frank-Starling curve (preload-responsive).
K-means clustering of the complete set of genes is consistent with Figure 1, but the inclusion of ~5,000 genes that are not clearly responsive leads to dampened curves and three non-responsive clusters (and consequently merging of three pairs of the original clusters) (Additional file 1).
