The ferrocenium cation, which is sensitive to glutathione (GSH), is a redox-responsive bond, and the positive charge of ferrocenium makes possible for the loading of negatively charged siRNA onto nanocarriers.
And bonding requires someone responsive to bond with.
Decisions to remit are fundamentally about allocation of resources in an extended family unit and are thus responsive to bonds of trust, emotion, and mutual obligation with the receivers of those resources (Carling, 2008; Menjivar et al., 1998).
Additionally, there are many –NH2 and –OH groups along the AX chain backbone, which deems the AX should be an excellent candidate for design of novel pH-sensitive nanomedicine with acid-responsive hydrogen bond [19].
In vitro drug release results indicates that the release of DOX at pH 5.0 is faster than that at pH 7.4, since DOX is conjugated to β-CD with pH-responsive hydrazone bond.
To date, no naturally occurring DNA-based enzyme has been discovered, but a rich field of DNA enzymes has been developed through in vitro selection for capabilities that include metal-responsive phosphodiester bond cleavage and ligation, amide bond synthesis, polymerase activity, Diels Alderase activity, porphyrin metalation, and others.
Moreover, SS-HPs show excellent gene transfection efficiency in vitro due to the breakdown of reduction-responsive disulfide bonds.
Besides, the HA prodrug micelles were cross-linked via reduction-responsive disulfide bonds to improve the stability of the micelles.
We anticipate this dual-responsive H-bond-directed chiral gel switch could propose a new strategy when researchers designing new, multi-responsive functional gel materials.
Because of the pH-responsive coordination bonding between TA and metal ions, the functional property of the metal-TA films was tailored for drug delivery.
This system is consisted of mesoporous silica nanoparticles as organic drug carrier, along with redox-responsive disulfide bonds for drug release into the cell at the same time.
