The proportion of responders to QFT-IT in HIV-infected individuals is similar to what has already been reported in the literature [6] [8], [11] and was significantly impaired in those defined as "mitogen-unresponsive" compared to the "mitogen-responsive", as previously shown [reviewed in 11].
This confirmed that, as previously shown [ 21, 22], human 6 16 and ISG12(a) are highly IFN-responsive in the human fibrosarcoma HT1080 cell line.
These samples were collected during surgical therapy of the sites that exhibited persistent bleeding on probing and increased probing depth three to four weeks after the basic periodontal therapy (non-responsive sites), as previously described [41].
To clarify this concern, we compared the identified phosphoproteins with the 4326 BR-responsive genes as previously described.
Finally, tissue inhibitor of metalloproteinase 3 (TisP3) is recognised as an HGF-responsive gene, as previously shown by Castagnino et al (1998).
RAW264.7 cell lines expressing wild-type and the drug-resistant mutant of SIK2 under a tetracycline responsive promoter were as previously described [ 13].
We utilized C2C12 myoblasts that have an integrated cassette expressing FLAG-tagged FRG1 under a tetracycline-responsive promoter iC2C12-FRG11) generased as previously described and kindly provided to us by Dr. Michael Kyba [17].
This screen identified phosphorylation sites on proteins with known roles in radiation responses including TP53BP1 as well as previously unidentified radiation-responsive proteins such as the candidate tumor suppressor SASH1.
The Learning from one another resulted in an approach to work that the participants described as more responsive than had previously been the case.
Out of a total of 161 transcripts defined as p53-responsive by previously described criteria [30], [31], 51 were changed at least 1.5 fold upon Cisplatin treatment of undifferentiated cells (Figure 5C, left panel; Table S1).
The hyperinsulinaemic phenotype of these mutations was mild and diazoxide responsive, as reported in the literature previously [ 9, 11, 12].
